Chloe, Max, Francesca, and Tania are successful supermodels. Despite promising careers, paranoia about their future plagues them as they age.
To counter the effects of aging, Van Swoon Cosmetics is developing a new cosmetic line, Superheroine, an advanced formula that uses nanobots carrying alpha particles that manipulate the wearer’s DNA. Bowing to corporate pressures, development of Superheroine is rushed. When the four models are exposed to the cosmetic during the launch party, they become ill and collapse.
When the girls awake, they learn that the nanobots have altered their DNA, giving them superhero powers. Max can conceal herself at will, Chloe’s hair can form into whatever she needs, Francesca’s smile emits a beam of light, and Tania’s nails fire from her fingers like bullets. Unknown to them, Tesa, a jealous corporate assistant, has also been exposed to the Superheroine cosmetic and threatens to use her newfound powers to threaten Angel City and become America’s top model….